As Katecholamine (also Catecholamin or Brenzcatechinamine) a set of body-own and artificial materials are summarized, which have an energizing effect at the sympathetic alpha and beta receptors of the heart circulation system. Thus the Katecholamine ranks among the Sympathomimetika. The Katecholamine is chemically similarly developed all (they all are Phenylethylamine) and the adrenalin used materials.

Katecholamine in the diagnostics

From the suprarenal body and from the sympathetic nerves set free Katecholamine Noradrenalin and adrenalin is separated to approximately 1% in the urine. 80-85% the Katecholaminausscheidung take place as and approx. 15% as Metanephrine.

With suspicion on Phaeochromocytom the regulation of free Noradrenalin and adrenalin are meaningful in the urine, since this usually good-like Tumore produces large quantities of Noradrenalin. The determination of the Katecholamine takes place thereby in the urine which was collected over 24 hours.

Katecholamine in the therapy

Katecholamine are available also as medicines. They are given almost exclusively in the intensive medicine and with Reanimation. They are strongly effective and are usually intravenously given. An alternative administration form with the Reanimation represents the endotracheale gift of adrenalin. This is meaningful if a Endotrachealtubus, but no intravenous entrance is available. The absorption speed is comparable, the dose must however be adapted.

With the Katecholaminanwendung for cycle stabilization in the intensive medicine is to be respected a very even supply into the body, since otherwise substantial pressure and heart frequency points, and/or (during interruption of the supply) blood pressure and heart frequency wastes can occur. A close heart cycle monitoring is indispensable, since these materials in higher dosage have a substantial arrhythmogenes potential (i.e. heartbeat disturbances up to ventricular fibrillations to release to be able). With application it to cardiac infarcts and brain bleedings can come by to high blood pressure.

The effectiveness of the Katecholamine with the cardiogenic shock is up to now not clearly occupied. Also otherwise the employment of the Katecholamine in the intensive medicine is based usually on empirical experience. Randomized comparative studies are goods in short supply, since the Katecholamine before the common acceptance of the criteria of the "Evidence stood based medicine" for order and their application the only way is often to maintain one with surviving agrees for cycle situation so that comparative studies with placebo arm for ethical reasons forbid themselves.

Substances

In the special one one summarizes under the term Katecholamin:

• Adrenalin
• Noradrenalin
• Dopamine
• Dobutamin
• Isoprenalin

Effects

• Rough organization in the low and middle dose range
  • Adrenalin
    • Blood pressure and heart frequency increases
  • Noradrenalin
    • Above all, not so much the heart frequency increases the blood pressure
  • Isoprenalin
    • Above all the heart frequency increases, not so much the blood pressure
  • Dopamine
    • positively inotropicly
  • Dobutamin
    • positively inotropicly

Side effects

• all are in higher dose arrhythmogen
• all are kardiotoxisch in high dose
• in high dose cycle centralization under Noradrenalin

Related links

Roche encyclopedia medicine:

• Katecholamin
• Illustration of the synthesis of the Katecholamine
• Table of the sympathomimetics

Articles in category "Katecholamin"

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